Upcoming Seminars **Example**:
- Guest Seminar 02/05/2021
By: Shay Stern, Biology, Technion
When: 02-May 2021 @ 02/05/21 12:30 – 02/05/21 13:30
Where: NBRL seminar room (Fishbach 430)
Description:
- Guest Seminar 10/05/2021
By: Uri Ben-David, Broad Institute
When: 03 Jan 2019 – 03 Apr 2016 @ 1/3/19 12:00 – 1/3/19 13:30
Where: NBRL seminar room (Fishbach 430)
Description:
Patient-derived models are invaluable for cancer research and cancer precision medicine. While tumor heterogeneity and genomic instability have received much attention lately, the heterogeneity and instability of cancer models – and how cancer model evolution affects cancer research – remain under-explored. We studied the genomic evolution of human cancer cell lines (CLs) and patient-derived xenografts (PDXs), using various genetic, transcriptional and phenotypic assays. Genomic analyses of 106 CLs grown in two laboratories revealed extensive genetic diversity. Follow-up comprehensive genomic characterization of 27 strains of the common breast cancer CL MCF7 uncovered rapid genetic diversification. Similar results were obtained with multiple strains of 13 additional CLs.
- Near Future Seminar 13/06/2021